The Food and Drug Administration (FDA) has approved the use of an OTC version of the prescription drug Orlistat (120mg). This approval was issued for the use of Orlistat 120mg.

Orlistat is the brand name for the prescription drug orlistat, also known as orlistat. It is used for the treatment of obesity, type 2 diabetes, high blood pressure and other conditions. It may also be used to reduce the risk of stomach ulcers and other stomach-related complications. Orlistat is FDA-approved for use in patients aged 18 and older, who have a BMI of 30 or greater, who have a BMI of 27 and are at risk of developing cancer, diabetes, high cholesterol or if they have obesity or high blood pressure. It is also approved to treat the symptoms of high blood pressure in adults and adolescents who have low blood pressure or are taking medications to lower blood pressure. Orlistat is available as a generic drug in Canada and as an over-the-counter (OTC) drug in the United States.

The OTC version of Orlistat may be available without a prescription or may be available under the brand name orlistat. Orlistat is also approved to treat an underactive thyroid gland and a type of cancer that is caused by the enlargement of the thyroid gland. It is also approved to treat the symptoms of thyroid cancer and to prevent the recurrence of the disease.

The Food and Drug Administration (FDA) has approved the use of orlistat (120mg) and its generic, semaglutide (agliptin), to treat obesity and related disorders.

The Food and Drug Administration (FDA) has approved the use of orlistat (120mg) and its generic, semaglutide (enalapril), to treat obesity and related disorders.

The Food and Drug Administration (FDA) has approved the use of orlistat (120mg) and its generic, enalapril, to treat obesity and related disorders.

Uses of Orlistat

Orlistat is used to treat obesity (Weight loss) along with a reduced calorie and lower-fat diet in adults (18 years and above).

Therapeutic Category

Orlistat: Anti-obesity drugs

How Orlistat works

Orlistat works by attaching to the enzymes in your digestive system (lipases) and preventing them from breaking down some of the fat that you’ve consumed during your meal. The fat that is not digested cannot be absorbed and it is removed by your body.

Common side effects of Orlistat

• flatulence with or without oily spotting
• sudden bowel motions
• fatty or oily stools
• soft stools
• stomach pain
• fecal incontinence
• runny or liquid stools
• more frequent bowel motions
• anxiety
• headache
• respiratory tract infection
• low blood sugar levels
• flu infection
• rectal pain or discomfort
• tooth or gum disorders
• urinary tract infection
• irregular menses
• tiredness

When to consult your doctor

Consult your doctor if you experience:

• severe allergic reactions (severe breathing problems, sweating, rash, itching, swollen face, rapid heartbeat, nausea, vomiting, feeling unwell)
• In case of accidental overdosage or ingestion

Health Tips for Orlistat

• Orlistat works best when combined with a reduced-calorie, balanced diet that contains moderate amounts of fat, carbohydrates, and protein. It is not a license to consume large amounts of high fat foods
• Drink plenty of water throughout the day to stay hydrated, especially if you experience diarrhea as a side effect of Orlistat
• Take Orlistat at the same time each day to maintain a consistent level of the medication in your system
• Orlistat is not recommended for use in pregnant and breast feeding women
• Orlistat can reduce the absorption of fat-soluble vitamins (A, D, E, K) and beta-carotene. To ensure you are getting adequate nutrients, consider taking a multivitamin supplement at least 2 hours before or after taking Orlistat

Costs

• igenous peoples who are especially sensitive to or intolerances by tests such as a blood test for gas or urine symptoms
• People who have a history of liver disease, high blood pressure, heart or blood vessel inactivity, mental health conditions, or are obese may experience more frequent frequent bowels
• frequent or severe headaches, meaning you may experience more than once bowel movements fewer than once every 24 hours, meaning you may experience more frequent bowel movements (less than once a week) than usual
• irregular heart or blood vessels, meaning you may experience more heart or blood symptoms, like anxiety, high blood sugar, needing to take a blood pressure medicine more than once a week
• irregular or arychologic bleeding, meaning you may have a bleeding history from any other type of bleeding, meaning you may have a more common or abnormal bleeding, like blood in your mouth, nose, or abdomen
• irregular or arychologic bruising, meaning you may have a bleeding history from any other type of bleeding, meaning you may have a more common or abnormal bleeding, like blood in your mouth, nose, or abdomen

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If you suffer from Peyrony synthoctline (‘curly potatoes’) cancer

Orlistat may rarely cause a condition known as lipases/thrombophilic metabolic acidosis. Orlistat is a drug that breaks down lipases to prevent them from attaching to blood vessels which reduces their effectiveness and increases the risk of heart attack and stroke.

Xenical is to treat people who are overweight or obese. This medicine works by targeting the absorption of dietary fat in your body rather than suppressing your appetite.

Dietary fats are large molecules that need to be broken down before they can be absorbed into the body. They are broken down by enzymes called lipases. That is, lipases play an important role in the digestion of dietary fat. When taken with a meal, Xenical interferes with the activity of these enzymes. This allows about 30% of the fat eaten in the meal to pass through the gut undigested. Therefore, your body cannot store these excess calories as fatty tissue or use them as a source of energy. This helps you to reduce your weight by burning up fat that you are already carrying, maintain your lower weight and minimise any weight regain. Losing even small amounts of weight and keeping it off produces additional health benefits for you, especially when you are at risk for other diseases such as heart disease and diabetes. Xenical can also help to improve risk factors, such as high blood pressure, high cholesterol and high blood sugar. If these are not treated, they could lead to other diseases such as hypertension and diabetes. Xenical should be taken in conjunction with a well-balanced calorie-controlled diet and other appropriate measures such as exercise.Active Ingredients:Xenical does not contain sucrose, gluten, tartrazine or any other azo dyes. Active ingredient - orlistat each Xenical capsule contains 120 mg orlistatInactive ingredients

• microcrystalline cellulose
• sodium starch glycollate
• povidone
• sodium lauryl sulfate
• talc [553].

DirectionsTake 1 capsule with each of the 3 main meals per day. It can be taken during the meal or up to 1 hour after the meal is consumed.Warnings & Disclaimers

• Keep your capsules in the blister pack until it is time to take them.
• If you take the capsules out of the packaging they will not keep well.
• Keep the blister pack in a cool dry place where the temperature stays below 25 degrees C.
• Do not store Xenical, or any other medicine, in a bathroom or near a sink.
• Do not leave it in the car or on window sills or other places where it may get hot, even for a short period.
• Heat and dampness can destroy some medicines.
• Keep Xenical where young children cannot reach it.

*** Please note that this product is a Scheduled Medicine in Western Australia. In order to ensure this product is appropriate and safe for you to use, we would appreciate it if you could respond to the following questions for us.

Who is this product for (Age and gender)?

What were you using this medication to treat?

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Read More What is Shingra and Why is Shingra Scheduled? Shingra is an oral diabetes medicine used for the treatment of obesity-related diseases in adults and children. It is an alternative to the traditional weight loss drug Wegovy and is not a controlled substance. It works by inhibiting the absorption of fat in the body rather than suppressing your appetite. Shingra is available in 3 forms: Tablet, oral capsule and Oral Solution.Share What Is Shingra and How Is It Used for Obesity-Related Diseases? It is an alternative to Wegovy and is not a controlled substance.

Overview

Xenical, the active ingredient in orlistat, is classified as a lipase inhibitor. This medicine is not recommended for use in pregnant women due to the potential risk of fetal harm. Xenical is indicated for weight loss in adults and adolescents over 18.

Pregnancy interaction

There are no known pharmacological interactions with Xenical, but there is a chance that Xenical may cause a low blood glucose in those taking it. The risk of glucose hyperglycemia may be higher in patients who have a body weight greater than 150 pounds.

What is orlistat?

Xenical is a prescription-only medicine. It is not usually given to children. The FDA recommends Xenical for use in adults only if it is prescribed for weight loss in children.

Xenical indications

Xenical is indicated for the management of obesity. Xenical may also be used in conjunction with a reduced-calorie diet or exercise program to lose weight. For more information, ask your doctor or pharmacist.

Xenical side effects

All Xenical side effects are possible with diet and exercise.

Xenical interactions

There is a chance that orlistat may interact with other medicines, foods, supplements, or medicines taken by mouth. This is a serious interaction. Your doctor will want to check if the medicine is safe to take with Xenical or if it may harm your health.

Xenical drug interactions

This medicine may be used for purposes other than those listed in this guideline. Be sure to tell your doctor and pharmacist about all the medicines, herbs, non-prescription drugs, or dietary supplements you take. Do not start a new medicine without telling your doctor.

Xenical dosage and administration

Your doctor will probably start you on a low dose and gradually increase it, depending on your age and medical condition. Xenical is usually taken every 3 months, starting with a lower dose and gradually increasing until you reach your weight-loss goals. Your doctor may check your blood sugar levels and adjust your dose as needed.

Xenical drug interactions with other medicines

Xenical may affect other medicines you take, including herbal medicines, over-the-counter medicines, and illicit drugs.

Ask your doctor or pharmacist before taking any other medicines, especially any that you buy without a prescription. Do not start a new drug without telling your doctor.

Xenical drug interactions with other medicines and foods

Before taking orlistat, tell your doctor or pharmacist if you are taking any of these:

• medicines used for weight loss
• medicines used for muscle pain
• medicines used to treat diabetes or to reduce the risk of heart disease.

Ask your doctor or pharmacist how to use the medicine safely. Your doctor will want to check your blood sugar levels and adjust your dose as needed.

Tell your doctor or pharmacist if you are taking, have recently taken, or have recently stopped taking any medicine for diabetes, a heart condition, or a stroke.

Tell your doctor or pharmacist what medicines, vitamins, nutritional supplements, or herbal products you are taking.

Orlistat is a prescription medicine. The FDA has approved it for:

• the treatment of obesity
• the treatment of type 2 diabetes
• the treatment of orlistat-associated weight loss

Orlistat is used in combination with a reduced-calorie diet and exercise to help lower blood sugar levels.In clinical trials, orlistat helped more people who have overweight or diabetes than they did people who did not have blood sugar levels lower.

Orlistat is also used to treat a rare condition called

• that is thought to be caused by fats being flushed into the body, which can then be absorbed and stimulate the metabolism
• In orlistat-treated overweight people, the drug helps reduce the fat that is made from the foods they eat

Orlistat is only for people who have a blood sugar level of

• hyperglycemia (diabetes sugar levels higher than 60 mg/dl);
• loss of appetite or weight
• nausea
• stomach pain
• fatigue
• reduced bone mineral density

Orlistat is only for prescription weight loss medications, so it is not recommended for use in children under 8 years of age without a medical reason.

Orlistat is also not approved for use by people who have a history of certain heart problems, high blood pressure, have had a recent heart attack, or have had stroke in the last 6 months.

ReferencesOrlistat.irb: access trials for. Accessed 26 May 2025

© 2022 The American Urological Association. Published by The National Academy of Sciences. Published by The National Academy of Sciences, 2013.

© The National Academy of Sciences, 2013.